DNA methylation screens

Research Project Tom Brabbs, Keygene

The aim of this project is to develop novel and cost-effective methods to detect genome wide changes in DNA methylation by using state-of-the-art equipment such as next generation sequencing platforms. As well as developing wet-lab techniques, this project will also involve creating bio-informatics tools to analyse the datasets generated. Assistance with the development of these methods and tools will be provided by our partners at Diagenode in Liège and IPG-PAS in Poznan. The DNA methylation detection methods can then be used, in conjunction with transcriptomic data, to elucidate the contribution of epigenetics to agriculturally important crop traits such as flowering time. This work on traits will be done in collaboration with the University of Amsterdam and the MPI for plant breeding in Cologne.