Mathematical modeling

Research Project Jean-Louis Dinh, University of Nottingham

The transition from vegetative growth to flowering is a remarkable process involving major changes in DNA quaternary structure as well as activation and repression of many genes. The time of flowering is dependent upon multiple factors which directly impact upon crop yield. The aim of this project is to gain a quantitative understanding of the processes involved, initially through developing static (graph theoretic) models, from which key components will be subject to deterministic dynamic modelling.

Based on pre-existing data sets, Jean-Louis Dinh will create and parameterise initial chromatin regulation models to provide a first mathematical view of the control of floral transition. Models will be refined and extended as new data emerge. The models will represent both inactive/active chromatin transitions and cis-acting gene regulation (using Hill or logistic functions). He will run simulations to generate hypotheses on the behaviour of the floral transition network for experimental testing. This will require ongoing interactions with all consortium partners.

Furthermore, the project will include secondments to partner companies where other smaller models will be developed.