Paul Fransz

University of Amsterdam/Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands

The aim of the Fransz lab is to understand the relation between the spatial organization of the eukaryote genome and chromosome function. The storage of genetic and epigenetic information in the nucleus involves the compaction of long chromatin fibres into a small nuclear subdomain. Simultaneously, the ’on demand availability’ of genetic information requires a highly efficient packing of chromatin. Our group investigates structure, formation and dynamics of chromatin domains in relation to (1) the linear DNA sequence, (2) gene expression and (3) nuclear reprogramming. We are especially interested in changes of the nuclear organization during plant development and in response to environmental stress. In addition, we investigate chromosome dynamics and the distribution of crossover events during meiosis. More…

The Fransz group is part of the Swammerdam Institute for Life Sciences (SILS) of the UvA, which is part of the Science Faculty (FNWI), one of Europe’s leading centers of education and research. SILS houses ~200 scientists in areas ranging from biology and biochemistry to data analysis and systems biology. The FNWI is housed in a brand new building with modern infrastructure and state-of-the art facilities. SILS features the well-equipped Centre for Advanced Microscopy. More…

Till Bey is the EpiTRAITS research fellow with the Fransz group, click to find out more about him and [[Nuclear organisation 1|his project]].