Maike Stam (coordinator EpiTRAITS)

University of Amsterdam, Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands

Gene expression is controlled by different mechanisms, including epigenetic modifications, intra- and interchromosomal interactions and chromatin folding. All these levels of gene control are essential for normal growth and development. The mission of Dr Maike Stam’s research group is to understand how epigenetic mechanisms and chromosomal interactions regulate gene expression and other chromatin-templated processes. Epigenetic gene regulation refers to mitotically or meiotically heritable changes in gene expression that involve changes in DNA methylation and chromatin structure. Chromosomal interactions refer to physical interactions between chromosomal regions, e.g. between regulatory elements and their cognate genes that may be located hundreds of kilobases away from each other. In the context of epigenetics and chromosomal interactions different studies are being performed in the group. More…

The Stam group is part of the Swammerdam Institute for Life Sciences (SILS) at the Faculty of Science (FNWI) of the University of Amsterdam (UvA). SILS is one of the Faculty’s largest institutes and houses about 200 scientists and staff members working in areas ranging from biology and biochemistry to data analysis and systems biology. The FNWI is housed in a new building with modern infrastructure and state-of-the-art facilities needed to carry out the EpiTRAITS project. More…

Blaise Weber is the EpiTRAITS research fellow with the Stam group, click to find out more about him and his project.